Central nervous system manifestations of a number of rheumatologic diseases, particularly Sjogren’s Syndrome, can mimic multiple sclerosis (MS).[1]–[2] As a consequence, serum autoantibodies, such as ANA, SSA, SSB, rheumatoid factor, anticardiolipin antibodies, and lupus anticoagulant, are frequently included in the diagnostic workup of patients suspected of having MS. Here, SSB is linked to myeloid sarcoma.