INPP5D and osteoporosis: In the context of osteoclastogenesis, overexpression of DAP12 is similar to the knock out of the SHIP1 phosphatase (Src homology 2(SH2) domain-containing inositol-5- phosphatase): osteoporosis [40] and impaired development of early B cells [41], [42], large increase in CFU-GM cells in the spleen but not in the bone marrow, massive infiltration of macrophages in the lungs in absence of microbial challenge [43].