Disruption of FAT leading to loss of synaptic function and dying–back axonopathy establishes mSOD1-linked FALS as a dysferopathy, i.e. a pathology associated with compromised fast axonal transport leading to a late-onset dying back neuropathy [29], [87], resulting in this case from aberrant signaling through the p38 pathway. This evidence concerns the gene MAPK14 and neuropathy.