CD4 and systemic sclerosis: On the other hand, the proportions of FrIII cells were markedly increased (6.23±2.29 vs 2.90±0.91 among CD4+, p<0.001; 73.71±9.62 vs 57.96±9.90 among Treg, p<0.001) in SSc patients compared to healthy controls, respectively.