In the Caucasian population, we found strong association of IDE rs6583813 with T2D (P = 1.33×10−12) but not with rs1583645 of CPE. Due to this inter-ethnic differences, we only included de novo genotyping and in silico analysis of GWAS data from the East Asian populations and confirmed the risk association for CPE rs1583645 [OR:1.09(1.02–1.16), P = 9.4×10−3] in the fixed effect model and IDE rs6583813 [OR:1.28(1.04–1.59), P = 0.02] in the random effect model. Here, IDE is linked to type 2 diabetes mellitus.