While these predictions need experimental confirmation, two of these TFs, upstream stimulating factor (USF) which binds to the G-allele and octamer binding factor 1 (Oct1 also known as POU2F1) which binds to the A-allele of CPE, are located within the chromosome 1q region which is the most replicable loci for T2D in multiple populations [34]. This evidence concerns the gene POU2F1 and type 2 diabetes mellitus.