Thus FBW7 heterozygosity results in increased Hes5 expression both in human colorectal tumours and in the APCmin;Fbw7ΔG/+ mouse model, suggesting that the NICD/HES5/FBW7β positive feedback loop is the molecular mechanism that underlies FBW7 haploinsufficiency in tumour suppression. This evidence concerns the gene FBXW7 and colorectal neoplasm.