FBXW7 and colorectal carcinoma: Mono-allelic FBW7 mutations are frequently observed in human colorectal cancer (CRC) and we described that also in the mouse Fbw7 heterozygosity greatly increased intestinal tumour number in the APCMin/+ mouse model [5], indicating that FBW7 haploinsufficiency in intestinal tumour formation is conserved between mouse and human.