The findings that FBXO28 depletion or expression of dominant-negative FBXO28 (ΔF-FBXO28) impairs MYC-induced oncogenic transformation and tumour growth indicate that FBXO28 is a rate-limiting factor in MYC-driven tumourigenesis, although we cannot rule out the possibility that FBXO28 ubiquitylates additional substrates and has MYC- and/or CDK-independent functions as well. Here, FBXO28 is linked to neoplasm.