The findings in this study of a mechanistic link between MYC activity and FBXO28, and the positive association between high FBXO28 expression and the expression of MYC target genes in human breast cancer suggest a potential role for FBXO28 in MYC-driven breast cancers and underscores the importance of FBXO28 as a new potential biomarker and candidate for future drug development, for instance via CDK inhibition, for the treatment of breast tumours with overexpression of FBXO28 and/or MYC. Here, MYC is linked to breast cancer.