The exact mechanisms by which mutant torsin A causes dystonia are still unclear, but there is accumulating data to suggest that torsin A is important for cellular compartments and pathways, including the cytoskeleton, the nuclear envelope, the secretory pathway and the synaptic vesicle machinery (Goodchild and Dauer, 2005; Goodchild et al., 2005; Hewett et al., 2006, 2007; Henriksen et al., 2009; Kakazu et al., 2012). Here, TOR1A is linked to Dystonia.