In the present study, we aimed to investigate the mRNA expression levels of DGCR8 and AGO2 in human CRC tissues and corresponding adjacent non-neoplastic tissues from male patients with same cancer, and examined the correlation of the mRNA levels of these miRNA machinery components with various clinicopathologic parameters, including age, tumor stage, BMI, and CEA titer. This evidence concerns the gene DGCR8 and neoplasm.