According to the metabolomic research, linoleic and palmitic acids belong to the metabolites, which were identified as potential biomarkers for diabetes mellitus.27 In a cohort of middle-aged normoglycemic men (n=895) in a Finnish prospective cohort study with follow-up after 4 years, men with a high proportion of LA in plasma fatty acids, indicating a high intake of dietary LA, had a lower risk of developing diabetes and showed lower increases in serum insulin and blood glucose over the follow-up period. Here, INS is linked to diabetes mellitus.