An increase in the content of the docosapentaenoic acid in muscle lipids after very low calorie diet was described previously.33 Docosapentaenoic acid was the only long-chain polyunsaturated n3 structural fatty acid that correlated with insulin sensitivity in patients with coronary artery disease.34 It cannot be ruled out, therefore, that docosapentaenoic acid may have a role in insulin action in the present setting. The gene discussed is INS; the disease is coronary artery disorder.