SIRT1 and chronic obstructive pulmonary disease: Moreover, resveratrol, probably by activating the SIRT1 signaling pathway, inhibits the oxidative-stress-dependent phenotypical shift of primary endothelial cells induced by pro-inflammatory factors in vitro [127].Further studies are required to investigate the role of resveratrol on inhibition of inflammation and cellular senescence by involving SIRT1 in lung cells, representing a promising therapeutic intervention for COPD [4].