TMPRSS2 and posterior cortical atrophy: Another promising RNA-based urinary biomarker is encoded by a fusion gene formed as a result of a translocation between the androgen-regulated transmembrane protease, serine 2 (TMPRSS2) gene transcriptional promoter and the ETS related oncogene (ERG), resulting in an androgen-regulated TMPRSS2–ERG fusion gene that is highly specific for PCa and can be found in approximately half of all white PCa patients [120].