In comparison, Daniunaite et al., (2011) report the high sensitivity of DNA methylation biomarkers in urine, especially that of RASSF1 (Ras association (RalGDS/AF-6) domain family member 1) and RARB (retinoic acid receptor beta) for the early and non-invasive detection of PCa. The gene discussed is RASSF1; the disease is posterior cortical atrophy.