The independent predictors of subclinical atherosclerosis in the < 40 y group were age, male sex, nonwhite race, stable partner, obesity and metabolic syndrome, and in the ≥ 40 y group they were age, male sex, stable partner, obesity, total cholesterol > 240 mg/dL, CD4 lymphocyte count > 350 cells/μl and duration on NNRTI ≥ 5 years. The gene discussed is CD4; the disease is Obesity.