Till now, more than 50 recurring genetic alterations have been identified, and many of the genes involved encode proteins with key roles in lymphoid development (PAX5, IKZF1, and EBF1), transcriptional regulation (ETV6, ERG), lymphoid signaling (BTLA, CD200, TOX, BLNK, VPREB1), cell-cycle regulation and tumor suppression (CDKN2A/CDKN2B, RB1, PTEN), and drug responsiveness (the glucocorticoid receptor NR3C1) [6]. This evidence concerns the gene IKZF1 and neoplasm.