PNPLA3 and hepatocellular carcinoma: Considering the roles of the SNP genotype of PNPLA3 with HCV-related HCC, a previous report by He et al. revealed impaired triglyceride hydrolysis in those with PNPLA3 148 M (He et al.2009), which might work against direct regulation of HCV in hepatic lipid metabolism, and suppress HCC development.