Liver steatosis and amino acid 70 of HCV core affected HCC development slightly (Hazards ratio 2.1, p = 0.067, and Hazards ratio 3.4, p = 0.082, respectively), while the SNP genotype of IL28B was not associated with the risk of HCC development (Hazards ratio 0.62, p = 0.31). The gene discussed is IFNL3; the disease is hepatocellular carcinoma.