P2X7-activated DCs have been shown to be crucial for the induction of tumor immunity (Ghiringhelli et al., 2009), the lack of P2X7 signaling decreases the severity of EAE (Sharp et al., 2008), and oxidized ATP (oxATP), an inhibitor of the ATP receptor P2rx7, ameliorated autoimmune type I diabetes and autoimmune encephalitis in mice (Lang et al., 2010). Here, P2RX7 is linked to neoplasm.