In our hands, DCs from lupus-prone mice express constitutively high levels of Type I IFNs and IFN responsive genes and this IFN Signature was diminished by treatment with oligonucleotides inhibitory for TLR7 and TLR9, supporting a role for the response of DCs to nucleic acids in the excessive production of Type I IFNs in lupus (Sriram et al., 2012). The gene discussed is TLR9; the disease is systemic lupus erythematosus.