Once diabetes has developed, hyperglycemia can induce HMGB1 secretion (Yao and Brownlee, 2010; Dandona et al., 2013) and HMGB1 may contribute to the nephropathy and the vascular complications of diabetes by fueling inflammation and promoting tissue damage, especially in the kidney (Lin et al., 2012). This evidence concerns the gene HMGB1 and kidney disorder.