Once diabetes has developed, hyperglycemia can induce HMGB1 secretion (Yao and Brownlee, 2010; Dandona et al., 2013) and HMGB1 may contribute to the nephropathy and the vascular complications of diabetes by fueling inflammation and promoting tissue damage, especially in the kidney (Lin et al., 2012). Here, HMGB1 is linked to Hyperglycemia.