Furthermore, there is no evidence within the mouse genomic sequence for the existence of sno-lncRNA, suggesting that the metabolic phenotype seen in the Snord116del mice is due to loss of 116HG. However, future studies will need to identify which of the RNAs generated from the Snord116 locus are critically lost in PWS, and if loss of multiple RNAs underlies the complex phenotype of PWS. Here, SNORD116 is linked to Prader-Willi syndrome.