CYBB and hyperinsulinemic hypoglycemia, familial, 4: Among the enzymatic pathways implicated in ROS generation and eventually 8‐iso‐PGF2α formation, NOX2, the catalytic core of NADPH oxidase, plays an important role, as suggested by the significant reduction of urinary and platelet 8‐iso‐PGF2α levels in patients with hereditary deficiency of NOX2.7 Conversely, subjects with NOX2 upregulation such as diabetic patients have opposite features, as shown by production of platelet 8‐iso‐PGF2α.8