This finding may help to explain previous findings showing a significant correlation between urinary excretion of 8‐iso‐PGF2α and 11‐dehydro‐thromboxane B2 and suggesting that changes in both variables reflect in vivo platelet activation.5–6 However, we cannot exclude that in diabetes the increase may stem from activation of other cells such as leukocytes and monocytes, which are also implicated in the activation of NOX2.12 Here, CYBB is linked to diabetes mellitus.