SIRT1 and cardiovascular disorder: Li and colleagues have shown that SIRT1 deacetylates and positively regulates this receptor, potentially altering cholesterol transport and metabolism.28 Although the exact mechanism of the improved lipid profiles seen with SIRT1 activation remains to be determined, our findings would suggest that SIRT1 activation could provide a therapeutic adjunct to current lipid‐lowering strategies, leading to improvements in cardiovascular disease pathophysiology and thus clinical outcomes.