Immunofluorescence staining revealed that abundant Ki-67+ tumor cells were observed in control mice, but mice injected with D283-ID3-shRNA had few Ki-67+ tumor cells (11.29 ± 3.67% in D283-control-shRNA vs. 6.00 ± 2.89% in D283-ID3-shRNA; P = 0.004; Student t-test; Figure 5C, F, I). The gene discussed is MKI67; the disease is neoplasm.