Genes such as FBLN1, ID1, FN1, LMO2, DCK, TLR4 which have important roles in tumor progression were up regulated in IGFBP2 positive tumors and were decreased upon IGFBP2 knockdown in breast cancer cells whereas genes such as SRPRB, POPDC3, ARHGEF4, KCNN4, BC11A which have negative role in tumorigenesis were down regulated in IGFBP2 positive tumors and were up regulated in IGFBP2 negative cells (p < 0.05). The gene discussed is SRPRB; the disease is breast cancer.