Elevated expression of IGFBP2 has been observed in multiple malignancies, including Glioblastoma multiforme [2-4], ovarian [5,6], pancreatic [7], gastric [8], prostate [9], colon [10], breast [11,12], leukemia [13] and thyroid cancer [14]. This evidence concerns the gene IGFBP2 and glioblastoma.