KEGG pathway analysis of common differentially regulated genes between IGFBP2 perturbed cells and IGFBP2 positive tumors revealed that the regulated genes belong to Glioma, Oxidative Phosphorylation, Apoptosis, Pathways in cancer and ErbB signaling pathway (Additional file 6: Table S4).Taken together, these data indicate that tumors with IGFBP2 expression phenotype are associated with distinct changes in expression of genes associated with the regulation of cell proliferation and tumorigenicity. Here, IGFBP2 is linked to central nervous system cancer.