Interestingly, the high level of expression of IgSF8, known to have an immunosuppressor role, by inhibiting T-cell mobility coordinately with CD81 [63], and the finding by other groups that extracellular HSPs exert immunomodulatory activities [62] suggest an important role of prom1-exo in the immune escape of FEMX-I melanoma. Here, CD81 is linked to melanoma.