Previous studies have shown that serum HMGB1 can serve as a biomarker for variety of cancers such as pancreatic ductal adenocarcinoma [23], colorectal carcinoma [24], malignant mesothelioma [25], canine lymphoma [26], non-small-cell lung cancer [27, 28], gastric cancer [29], and hepatocellular carcinoma [30]. This evidence concerns the gene HMGB1 and malignant mesothelioma.