KEAP1 and malignant colon neoplasm: In order to confirm the effect of KEAP1-knockdown on NRF2 target genes expression and oxidative stress susceptibility, another type of colon cancer cell line HCT116, which has a distinct genetic mutation profile [35–43], was used for the establishment of stable KEAP1 knockdown cell line (shKEAP1 HCT116).