TLR9 and pulmonary tuberculosis: In this study, there was not any evidence for a significant association of TLR4 Asp299Gly and Thr399Ile and TLR9 T-1486C polymorphisms with pulmonary TB risk, but the combination effect of TI,II/CC genotypes for TLR4 Thr399Ile and TLR9 T-1486C polymorphisms showed 7.5-fold increased risk of pulmonary TB which was slightly significant (P = 0.047).