MMP2 and neoplasm: In the groups with >6 years of androgen blockade the expression of stromal MMP-2 increases rapidly and significantly, which suggests that micrometastatic MMP-2 expression may in some way activate stromal MMP-2 expression; in other words “the seed” modulates “the soil.” The increased expression of stromal MMP-2 would increase the neovascularization and thus support rapid tumor growth.