CDK4 and sarcoma: Amplification and overexpression of MDM2, CDK4, GL1 and SAS genes of the 12q13-15 region has been associated with other sarcomas such as well-differentiated and dedifferentiated liposarcoma, leiomyosarcoma, and a significant subset of alveolar and embryonal rhabdomyosarcomas [18] and even sclerosing epithelioid fibrosarcoma [19].