INSR and Hyperinsulinemia: Lesson 7: Insulin Receptor Signalling on Pancreatic Islets Is Not Required for Beta Cell Compensatory Response to Severe Insulin Resistance. The severe hyperinsulinemia seen even in those with almost complete loss of insulin receptor function suggests that the insulin receptor on pancreatic islets is not necessary for beta cell functioning, as has been suggested by some studies in mice [108].