A mutation in v-akt murine thymoma viral oncogene homolog 2 (AKT2) has been identified accounting for the clinical features of acanthosis nigricans, ovarian hyperandrogenism, diabetes mellitus, and in contrast to those with insulin receptor mutations, both metabolic dyslipidemia and fatty liver in the proband [111]. The gene discussed is AKT2; the disease is acanthosis nigricans.