Totally 8 SNPs in 3 genes, COMT, HTR3B, CHRM3 (rs1176744, rs3782025, rs1672717, rs165722, rs4680, rs4633, rs10802789, rs685550), were significantly associated with the interindividual differences in nausea and vomiting among cancer patients treated with opioids [21]. The gene discussed is COMT; the disease is cancer.