Laugsand et al. analyzed 96 single-nucleotide polymorphisms (SNPs) in 16 candidate genes related to opioid or nausea/vomiting signaling pathways (ABCB1, OPRM1, OPRK1, ARRB2, STAT6, COMT, CHRM3, CHRM5, HRH1, DRD2, DRD3, TACR1, HTR3A, HTR3B, HTR3C, and CNR1) for the association with nausea and vomiting in the same cohort of cancer patients. This evidence concerns the gene COMT and cancer.