Two recent meta-analyses found that non-STin2.12 alleles possess protective effect compared to STin2.12 alleles, respectively, 10/12 and 10/10 genotypes compared to the 12/12 genotype against migraine among populations of European descent [108], while no overall association between the SLC6A4 5-HTTLPR polymorphism and migraine among Europeans and Asians was found, though gender and migraine aura status may have modifying roles among Europeans [236]. The gene discussed is SLC6A4; the disease is migraine disorder.