IL33 and arthritic joint disease: Thus, IL-33 was initially identified as a possible target for dampening inflammation in several animal models of inflammatory diseases, such as airway inflammation and arthritis (i.e., ovalbumin challenge-induced airways inflammation and collagen-induced arthritis) [44–46] since it was well established that IL-33 had the ability to promote inflammation through both the recruitment [47] and activation [48] of immune cells to the site of inflammation, as demonstrated by data obtained in a Th2 cell adoptive transfer model and in vitro.