Despite its well-known proinflammatory properties, IL-33 has also shown protective functions in different diseases; in fact, early reports demonstrated that IL-33 exerts a cardioprotective effect, reducing overload-induced cardiomyocyte hypertrophy [66]; on the same line, Miller et al. showed that IL-33 reduced the development of atherosclerosis [37] and the inflammation within the adipose tissue of obese mice [67], confirming the beneficial effect of IL-33 on the cardiovascular system. Here, IL33 is linked to atherosclerosis.