Data regarding the analysis of IL-33 expression in human IBD were closely recapitulated in SAMP1/YitFc (SAMP) mice [35], a spontaneous model of chronic intestinal inflammation immunologically characterized by an early Th1 response and a later mixed Th1/Th2 phenotype [39], both significantly contributing to the extent of disease severity in these mice [40, 41]. This evidence concerns the gene IL33 and gastroenteritis.