For example, it has been shown that in the inflamed mucosa of IBD patients and colitis models, there is a perturbation of the balance between the proinflammatory cytokine, IL-1, and its naturally occurring antagonist, the IL-1 receptor antagonist (IL-1Ra), and that restoring this balance by exogenous administration of IL-1Ra ameliorates intestinal inflammation [2, 3]. Here, IL1B is linked to inflammatory bowel disease.