Interestingly, Sedhom et al. demonstrated on both DSS- and TNBS-induced colitis that, during the onset of intestinal inflammation, the IL-33/ST2 axis activation was able to affect the non-haematopoietic component of the inflammatory response, resulting in a significant impairment of the epithelial barrier function [64]. The gene discussed is IL1RL1; the disease is colitis.