As UVRAG-mediated activation of the Beclin-1-PI(3)KC3 complex promotes autophagy and suppresses the proliferation of cancer cells [29], we examined the effect of siRNA against UVRAG on autophagic cell death induced by SG511-BECN to demonstrate indirectly whether overexpression of Beclin-1 contributes to cell death of leukemia. This evidence concerns the gene BECN1 and leukemia.