Because UVRAG, a Beclin-1-interacting protein, associates with the Beclin-1-Bcl-2-PI(3)KC3 multiprotein complex, where UVRAG and Beclin-1 interdependently induce autophagy [29], reversal of the antileukemic effects of SG511-BECN by knockdown of UVRAG also demonstrated that autophagic cell death contribute to the enhanced cytotoxicity of the virus against leukemia cells. This evidence concerns the gene BECN1 and leukemia.