MTOR and cancer: The median TTF was significantly longer in nine patients (one patient [case #17; Table 2] was not included in the paired analysis as the patient did not receive prior systemic therapy for advanced cancer) treated on mTOR inhibitor combinations (11.6 months, 95% CI, 0.0–30.9 months) compared to median TTF on their last standard therapy prior to referral to the phase I clinic (2.3 months, 95% CI, 1.7–2.9 months; p=0.024; Figure 2B).