EGFR and Hypoglycemia: To determine whether either hypoxia or hypoglycemia alone was sufficient to increase the expression of the EGF-R, rat neurospheres were exposed to either hypoxia (2% oxygen/5%CO2/93% N2) or hypoglycemia (3 mM glucose) for 4 h following which the cells were returned to standard neurosphere culture conditions for 24 h.