A statistically significant reduction in CRP, IL-6, and other inflammatory biomarkers was observed after the administration of anti-IL-1β antibodies in T2DM patients, suggesting a prominent role of this cytokine in the induction of the chronic inflammatory state characterizing the disease [47, 48] and its possible involvement in the subsequent alteration of the adaptive immune response [49]. This evidence concerns the gene CRP and type 2 diabetes mellitus.