SERPINE1 and type 2 diabetes mellitus: Conversely, systemic inflammation can itself predispose to the onset of insulin resistance and consequently T2DM, as shown by several studies demonstrating that high levels of inflammation markers (including CRP, fibrinogen, IL-6, and plasminogen activator inhibitor PAI-1) could predict the risk of developing T2DM [7, 8, 11, 12].