CD4+CD28null T-cells and Treg were also similar in T2DM patients with or without micro- or macrovascular complications, while hs-CRP levels were significantly higher in T2DM patients with macrovascular complications (median 4.3, range 0.5–21.9 versus median 2.0, range 0.5–14.6; P = 0.047). Here, CD4 is linked to type 2 diabetes mellitus.