In addition, Frittitta et al. [45] described a haplotype (a cluster of three single nucleotide polymorphisms: rs1044548G/A, rs11964389G/C, and rs1044558C/T) in the 3′-untranslated region of the ENPP1 gene that may modulate ENPP1 expression and confer an increased risk for insulin resistance. The gene discussed is ENPP1; the disease is Insulin resistance.