Overall, solid evidence seems to exist only for rs1044498 of the ENPP1 gene and for rs2295490 of the TRIB3 gene, whose association with T2D risk and insulin resistance, even if not confirmed (for ENPP1) [33] or not yet investigated (for TRIB3) [33] by GWAS studies, has been consistently reported by several original studies [16–20, 22–33, 38–43, 100, 101, 103, 104] and large meta-analyses [32, 104]. This evidence concerns the gene ENPP1 and Insulin resistance.