Repeat labs were sent on HD 21, and his baseline cortisol at 9:47 am was 0.4 mcg/dL, and the cortisol level 60 minutes post-ACTH (125 mcg) stimulation test was also low at 7.8 mcg/dL (a level less than 18 mcg/dL is diagnostic of adrenal insufficiency). Here, POMC is linked to Adrenal insufficiency.