These data suggest the possibility that expression of nonfunctional CXCL14/BRAK molecules might be associated with stimulation of tumor growth in several adenocarcinoma cells, whereas normal functioning CXCL14/BRAK molecules might suppress tumor growth in vivo in adenocarcinoma as well as in HNSCC. This evidence concerns the gene CXCL14 and head and neck squamous cell carcinoma.