However, by individual type of thrombophilia, compared to noncarriers, the adjusted HR for the development of PTS was 0.42 (95% CI, 0.20–0.88; P = 0.02) in carriers of factor V Leiden, 0.81 (0.36–1.37) in carriers of lupus anticoagulant, 0.96 (0.29–3.82) in carriers of protein C deficiency, 1.08 (0.29–2.70) in carriers of protein S deficiency, and 1.33 (0.68–2.58) in carriers of prothrombin G20210A mutation. This evidence concerns the gene F2 and protein c deficiency.