IL2 and pulmonary embolism: While pulmonary embolism has been reported to be fatal in <1% of patients undergoing treatment with HD IL-2 [1], the patient who had a pulmonary embolism (Patient 3) during treatment actually had the longest survival in this analysis (19.0 months from initiation of HD IL-2 and 23.5 months from diagnosis of melanoma brain metastasis).