The lower levels of urinary AA metabolites, serum DHEA, and DHEAS in premenopausal early RA patients and the recent findings of baseline lower serum cortisol, as well as a truncated upper range of Δ4A levels in a minority of pre-RA versus CN female cohort subjects, have prompted this further analysis of a comprehensive panel of adrenal cortical and sex steroids in our pre-RA and CN cohort subjects [15, 16]. Here, SULT2A1 is linked to rheumatoid arthritis.