CYBB and Hypertension: NOX derived O2− is enhanced in hypertension, and this is linked with the increased expression of NOX subunits (NOX2, p22phox, p47phox).[16], [17] In the present study, canola oil intake alone increased p22phox and NOX2 expression, whilst canola oil in combination with salt intake reduced p22phox mRNA expression compared to the canola oil group without salt.