In addition to the role in promoting tumor cell invasiveness, we speculate that the Gα12 induction of IL-6 and IL-8 production might also be involved in the drug resistance of OSCC, because several cytokines, including IL-6 and IL-8, are known to contribute to drug resistance in several different cancer types [46]–[48]. Here, CXCL8 is linked to neoplasm.