PARP1 and Miyoshi myopathy: We found that bufalin induced G2-M arrest in MM cells [37], an observation which may also reflect the inhibition of PARP1 activity; (e) PARP1 consists of three distinct domains: the DNA-binding domain, which plays a key role in recognition of DNA lesions; the auto-modification domain, which provides protein-gathering sites; and the catalytic domain, which poly(ADP-ribosyl)ates histones and PARP1 itself [38].