AGTR1 and heart failure: In a model of ADR-induced heart failure in Male Sprague-Dawley rats, Zong et al (2011) detected a decrease of plasma Ang-(1–7) levels and reduced myocardial expression of Mas receptor, while the treatment with telmisartan or losartan increased Ang-(1–7) levels and suppressed myocardial AT1 receptor expression without changing the expression of Mas [58].