It is conceivable therefore that NFAT1 may, under some conditions, play a similar role in T cells and tumor cells, and particularly in the highly invasive and proliferative GBM [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], given that the immune system plays a significant role in the formation and development of glioma. Here, NFATC2 is linked to central nervous system cancer.