MIP and diabetes mellitus: To define the combined effects of sub-optimal islet mass, immunosuppression, Pio and alogliptin, we developed a model of syngeneic islet transplantation where only 50–75 MIP-luc islets were transplanted under the kidney capsule of syngeneic albino C57BL/6 mice that had been pre-treated with STZ to induce diabetes (Fig. 5a).