CCNB1 and cancer: Our study shows that mitotic response pathways are highly deregulated in the OVCAR-3-TR and SKOV-3-TR cancer cells, evidenced by down-regulation of cyclin B1, depletion of mitotic spindle checkpoint protein BubR1, and inability to activate mitotic epitope MPM-2 in resistant cells when compared with the parental cells (Figure 5A, B).