PTEN and neoplasm: Besides inhibiting the expression of E-cadherin (Figs. 6A&B), SNAI1 also been shown to inhibit the expression of epithelium-specific genes such as PTEN, Muc1, and some nuclear factor receptors [33], and in addition to its association with tumor metastasis, SNAI1 is also associated with other cancer hallmarks such as p53.