CDH1 and breast carcinoma: Although only 58% of the samples displayed high level of AIB1, 72% of these also displayed high level of SNAI1 with no detectable E-cadherin expression (Fig. 7B), which is in agreement with our speculation that AIB1 synergistically induced SNAI1 expression and E-cadherin repression, resulting in induction of EMT in the progression of breast cancer.