In the present study, we found TGF-β1 increased the deposition of ECM FBLN-1 protein by human ASM cells from both people with COPD and without COPD, whereas TGF-β1 decreased the soluble FBLN-1 from both COPD and non-COPD ASM cells. This evidence concerns the gene FBLN1 and chronic obstructive pulmonary disease.