Recently published data suggests that overexpressed YAP may interplay with β-catenin to drive proliferation of colon cancer cells, implying that YAP could play a role in cancer therapy [17]; however, to our knowledge, research into the clinical significance of YAP and TAZ, and the prognostic value of YAP and TAZ, has been limited, and the significance of YAP and TAZ co-overexpression in CRC, remains elusive. This evidence concerns the gene WWTR1 and colonic neoplasm.