The group that was co-transfected with YAP and TAZ siRNAs showed the most dramatic, and highly significant (P<0.05), decrease in proliferation rate compared to the parental or control siRNA groups (Figure 4B); therefore, these results demonstrated that YAP and TAZ possessed a synergistic role of on the proliferation of colon cancer cells. Here, WWTR1 is linked to malignant colon neoplasm.