WWTR1 and colorectal carcinoma: Based on the established views that YAP may increase organ size, and function as an oncogene [5], [9]; and that TAZ may promote cell proliferation, induce epithelial-mesenchymal transition (EMT), and increase cell migration and invasion [22]; combined with the potential similarity of tissue-specific functions of YAP and TAZ, we examined and characterized the clinical significance of YAP and TAZ as an independent prognostic factor for determining the outcomes of CRC patients.