Based on the established views that YAP may increase organ size, and function as an oncogene [5], [9]; and that TAZ may promote cell proliferation, induce epithelial-mesenchymal transition (EMT), and increase cell migration and invasion [22]; combined with the potential similarity of tissue-specific functions of YAP and TAZ, we examined and characterized the clinical significance of YAP and TAZ as an independent prognostic factor for determining the outcomes of CRC patients. Here, YAP1 is linked to colorectal carcinoma.