YAP1 and cancer: TAZ is a YAP paralog, initially identified as a 14-3-3 binding protein [23]; TAZ has approximately 50% sequence identity with YAP, and a similar topology; TAZ acts as a transcriptional co-activator in similar manner to YAP [23]; of note, was the discovery that YAP and TAZ share the downstream transcription factor, TEAD, to promote cell proliferation, migration, anchorage-independent growth, and EMT, which are all involved in cancer initiation and progression [24].